Acetic Anhydride → HCID 70072529, compound

Participants

Reaction Steps

To a suspension of 4-amino-5-chloro-2-methoxy-N-((1-(6-(4-hydroxyphenyl)-6-oxohexyl)piperidin-4-yl)methyl)benzamide (10.0 g) in dichloromethane (60 ml) were added triethylamine (12.5 ml) and acetic anhydride (2.5 ml), and the resulting mixture was stirred at room temperature for 1 hr. The reaction mixture was concentrated under reduced pressure. Water was added to the residue and the mixture was extracted with chloroform. The organic layer was washed with brine and dried. The solvent was evaporated under reduced pressure and the obtained crystals were recrystallized from a mixed solvent of ethanolethyl acetate to give 8.50 g of 4-amino-5-chloro-2-methoxy-N-((1-(6-(4-acetoxyphenyl)-6-oxohexyl)piperidin-4-yl)methyl)benzamide acetate, m.p. 140°-141° C.

Provenance & Evidence