HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 4-amino-N-((1-(3-benzyloxypropyl)piperidin-4-yl)methyl)-5-chloro-2-methoxybenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Benzyl 3-Bromopropyl Ether | HCID 2776064 | — |
| Reactant | 4-amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride | HCID 69966330 | — |
| Product | 4-amino-N-((1-(3-benzyloxypropyl)piperidin-4-yl)methyl)-5-chloro-2-methoxybenzamide | HCID 54408657 | 98.4% |
Reaction Steps
4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride (6 g) as a starting compound, potassium carbonate (10.1 g) and 3-benzyloxypropyl bromide (4.45 g) were reacted and treated in the same manner as in Example 199 to give 7.1 g of 4-amino-N-((1-(3-benzyloxypropyl)piperidin-4-yl)methyl)-5-chloro-2-methoxybenzamide, m.p. 82°-83° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05864039 |
| Source dataset | uspto-grants-1999_01 |
| ORD ID | ord-06ab9a11547c44e8a9e2375f5768bb1d |
| Source note | uspto-grants-1999_01 |