Sodium Hydroxide → HCID 14550002, compound

HRID 344562Notes

Reaction equation

HRID 344562 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[C:6]([CH2:11][S:12][CH2:13][CH2:14][OH:15])[CH:5]=1)([O-])=O.[OH-].[Na+].S(S([O-])=O)([O-])=O.[Na+].[Na+]>O>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[C:6]([CH2:11][S:12][CH2:13][CH2:14][OH:15])[CH:5]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 24489Sodium DithioniteHCID 14550001HCID 14550001, compound

Product 1

HCID 14550002HCID 14550002, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

0.085 moles (19.5 g) of 4-nitro-2-[(β-hydroxyethylthio)methyl]phenol are added to a solution of 16 g of sodium hydroxide (NaOH) pellets in 135 ml of water, followed portionwise, so as to maintain the temperature between 70° C. and 75° C., by 55 g of sodium hydrosulphite. After the end of addition stirring is continued for 20 minutes at 75° C. After cooling, the expected product is precipitated by neutralizing the reaction mixture with acetic acid. After filtering off, followed by washing with water and drying, the product obtained is recrystallized from acetonitrile. It melts at 121° C.

Workup

  1. temperatureso as to maintain the temperature between 70° C. and 75° C.
  2. additionAfter the end of addition
  3. temperatureAfter cooling
  4. customthe expected product is precipitated
  5. filtrationAfter filtering off
  6. washby washing with water
  7. customdrying
  8. customthe product obtained
  9. customis recrystallized from acetonitrile

Sources & evidence

ORD record
ord-8312f326eee8430fa7280d193ade6b7f
Source dataset
uspto-grants-1991_10
Patent number
US05053052

Reaction notes

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