化工社化工社 化学情報印刷レポート · 研究参考用
O-Methylhydroxylamine → 0-Methyl-2-(4,6-dimethoxy-2-pyrimidinyloxy)benzaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | O-Methylhydroxylamine | HCID 4113 | — |
| 反応物 | Benzaldehyde, 2-[(4,6-dimethoxy-2-pyrimidinyl)oxy]- | HCID 820623 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 0-Methyl-2-(4,6-dimethoxy-2-pyrimidinyloxy)benzaldehyde | HCID 88512626 | 103.3% |
反応手順
In 100 ml of methanol, 5.2 g of 2-(4,6-dimethoxy-2-pyrimidinyloxy)benzaldehyde and 1.0 g of methoxyamine were dissolved. The solution was stirred at room temperature for 2 hours. After the methanol was distilled out under reduced pressure, the resulting residue was purified by silica gel chromatography (developer: n-hexane:ethyl acetate=10:1) to obtain 5.7 g of 0-methyl-2-(4,6-dimethoxy-2-pyrimidinyloxy)benzaldehyde as an oily substance.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05053070 |
| 出典データセット | uspto-grants-1991_10 |
| ORD ID | ord-3b97b9e1659946e78fab041bfe9d304a |
| 出典メモ | uspto-grants-1991_10 |