Phosphorus tribromide → 1-Bromo-3-methylheptane

HRID 344628Notes

Reaction equation

HRID 344628 reaction equation
P(Br)(Br)[Br:2].[CH3:5][CH:6]([CH2:10][CH2:11][CH2:12][CH3:13])[CH2:7][CH2:8]O>>[Br:2][CH2:8][CH2:7][CH:6]([CH3:5])[CH2:10][CH2:11][CH2:12][CH3:13]

Participants

3

Reactant 2

HCID 24614Phosphorus tribromideHCID 5178833-Methyl-1-heptanol

Product 1

HCID 142782001-Bromo-3-methylheptane

Conditions

Temperature
100 °C

Procedure

Phosphorus tribromide (10.44 g, 38.5 mmol) is added dropwise to 95% 3-methyl-1-heptanol (7.7 g, 56.3 mmol) at 0° C. and the mixture is stirred for 5 h at 100° C. The mixture is allowed to cool, poured onto ice, and extracted several times with hexane. The extract is washed with sodium carbonate solution, dried over magnesium sulfate, and evaporated down.

Workup

  1. temperatureto cool
  2. additionpoured onto ice
  3. extractionextracted several times with hexane
  4. washThe extract is washed with sodium carbonate solution
  5. dry with materialdried over magnesium sulfate
  6. customevaporated down

Sources & evidence

ORD record
ord-43277d2dc7404150aeb4511a1612b716
Source dataset
uspto-grants-1991_10
Patent number
US05053223

Reaction notes

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