Hexahydro-1,4-diazepine → 2-(1,4-Diazepan-1-yl)-5-propylbenzene-1-sulfonic acid

HRID 344664Notes

Reaction equation

HRID 344664 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH3:10])=[CH:4][C:3]=1[S:11]([OH:14])(=[O:13])=[O:12].[NH:15]1[CH2:21][CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1>>[N:15]1([C:2]2[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH3:10])=[CH:4][C:3]=2[S:11]([OH:14])(=[O:13])=[O:12])[CH2:21][CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 68163Hexahydro-1,4-diazepineHCID 14994783HCID 14994783, compound

Product 1

HCID 98574372-(1,4-Diazepan-1-yl)-5-propylbenzene-1-sulfonic acidYield 37.2%

Procedure

According to the same method as in Example 2, from 0.61 g of 2-fluoro-5-n-propylbenzenesulfonic acid and 2.80 g of homopiperazine, 0.31 g (yield: 37.2%) of the above title product having the following physical property was obtained.

Sources & evidence

ORD record
ord-9de7aacdef4d42aea1e1fcaea3cac336
Source dataset
uspto-grants-1991_10
Patent number
US05053409

Reaction notes

Loading…