1,2-Dibromoethane → 1-(2-Chloroethyl)-3-methyl-1H-pyrazole

HRID 344677Notes

Reaction equation

HRID 344677 reaction equation
[CH3:1][C:2]1[CH:6]=[CH:5][NH:4][N:3]=1.Br[CH2:8][CH2:9][Cl:10].BrCCBr>C1(C)C=CC=CC=1>[CH3:1][C:2]1[CH:6]=[CH:5][N:4]([CH2:8][CH2:9][Cl:10])[N:3]=1.[CH3:1][C:2]1[CH:6]=[CH:5][NH:4][N:3]=1

Participants

6

Reactant 3

HCID 78391,2-DibromoethaneHCID 78491-Bromo-2-ChloroethaneHCID 178428694HCID 178428694, compound

Product 2

HCID 137648531-(2-Chloroethyl)-3-methyl-1H-pyrazoleHCID 178428694HCID 178428694, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

When an equivalent amount of 3-methylpyrazole is substituted for 1-ethoxycarbonyl-2H-indazolin-3-one and 2-bromochloroethane is substituted for 1,2-dibromoethane in the procedure of Example 19 using toluene as solvent, 2-(3-methyl-1H-pyrazol-1-yl)ethyl chloride is isolated after column chromatography (3-methylpyrazole, Aldrich, 36%, C).

Sources & evidence

ORD record
ord-b098403c0d2a4d32a230199d54b2d20b
Source dataset
uspto-grants-1991_10
Patent number
US05053411

Reaction notes

Loading…