Diethyl Ether → HCID 67925099, compound

Participants

Reaction Steps

3.64 g of [1-methyl-3-(4-methylthiazol-2-yl)-1,2,5,6-tetrahydropyridine] is dissolved in 70 cm3 of dichloroethane, 2.95 g of alphachloroethyl chloroformate is added at 0° C. under inert atmosphere, and the whole is heated under reflux for one hour 30 minutes. The solvent is eliminated, te residue is taken up with ether and filtered. The filtrate is concentrated to dryness, the residue is taken up in 40 cm3 of methanol and heated for 30 minutes under reflux. The solvent is eliminated and the residue is crystallized twice from ethanol and ether and 2.67 g of expected product is obtained. M.p.=184°-185° C. (decomp.).

Provenance & Evidence