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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 344699Generated: October 29, 2026

Methanol → HCID 70045154, compound

https://huagongshe.com/reaction/344699

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanolHCID 887—
ReactantPotassium CarbonateHCID 11430—
Reactant2-[(2S)-1-[3-(N-benzyl-N-methylcarbamoyl)propanoyl]pyrrolidin-2-yl]-2-oxoacetic acid ethyl esterHCID 15660922—
SolventWaterHCID 962—
ProductHCID 70045154HCID 70045154150.4%

Reaction Steps

A mixture of 2-[(2S)-1-[3-(N-benzyl-N-methylcarbamoyl)propanoyl]pyrrolidin-2-yl]-2-oxoacetic acid ethyl ester (626 mg), potassium carbonate (277 mg), methanol (7 ml) and water (4 ml) was stirred for 1 hr. at room temperature. Water was added to the reaction solution. The mixture was extracted with EtOAc. The extract was washed, dried and evaporated to give the title compound (458 mg) having the following physical data:

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05053414
Source datasetuspto-grants-1991_10
ORD IDord-fbd41eda569743b2b99513ec9d1f8e99
Source noteuspto-grants-1991_10