HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 344712Generated: October 30, 2026
Urea → 6,7,8-Trimethoxyquinazoline-2,4(1H,3H)-dione
https://huagongshe.com/reaction/344712
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Urea | HCID 1176 | — |
| Reactant | 3,4,5-Trimethoxyanthranilic acid | HCID 96602 | — |
| Solvent | Water | HCID 962 | — |
| Product | 6,7,8-Trimethoxyquinazoline-2,4(1H,3H)-dione | HCID 5743421 | 45.1% |
Reaction Steps
A mixture of 4.94 g (21.7 mmols) of 3,4,5-trimethoxyanthranilic acid and 15.15 g (249.8 mmols) of urea was heated at 145° C for an hour with stirring. After cooling, water was added and the mixture was heated at the boiling point with stirring. The solid was taken out by filtration and dried to afford 2.47 g (yield: 45%) of 6,7,8-trimethoxyquinazoline-2,4-dione.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05053408 |
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| Source dataset | uspto-grants-1991_10 |
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| ORD ID | ord-a2fb4af130ef44948c9087476214cf59 |
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| Source note | uspto-grants-1991_10 |
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