反应详情

A mixture of 6-cyano-3,4-dihydro-2,2-dimethyl-3,4-epoxy-2H-1-benzopyran-3-ol (0.927g) and ethylenediamine (2.78g) was heated under reflux in ethanol (70 ml) for 16 h. The solvent was evaporated in vacuo and the residue column chromatographed (Kieselgel 60, gradient elution: 0-9% 880 ammonia-methanol) giving the title compound (0.868g) as a foam.

1. temperaturewas heated
2. customThe solvent was evaporated in vacuo
3. customthe residue column chromatographed
4. wash(Kieselgel 60, gradient elution: 0-9% 880 ammonia-methanol)