HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl N-cyanodithioiminocarbonate → HCID 178431170, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl N-cyanodithioiminocarbonate | HCID 66289 | — |
| Reactant | trans-4-(2-Aminoethylamino)-6-cyano-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-3-ol | HCID 15680853 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 178431170 | HCID 178431170 | 98.1% |
Reaction Steps
A mixture of trans-4-(2-aminoethylamino)-6-cyano-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-3-ol (D3) (0.39g) and dimethyl N-cyanodithioiminocarbonate (0.158g) was heated under reflux in toluene (30 ml) for 71 h. The solvent was evaporated in vacuo, and the residue column chromatographed (Kieselgel 60, gradient elution: 2-7% methanol-chloroform) giving the title compound as a white solid (0.33g). Recrystallisation from ethyl acetate-ether gave a sample of m.p. 257°-260° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05053427 |
| Source dataset | uspto-grants-1991_10 |
| ORD ID | ord-57b3616783734e4a8fa0c1ecb97e6c2e |
| Source note | uspto-grants-1991_10 |