反应详情

In 210 ml of 1N ethanol solution of potassium hydroxide was dissolved 28 g (0.1 mole) of the R-form of 1-(4-(1-ethoxyethoxy)phenyl)ethyl butyrate obtained in Example 2 (i), (ii) or (iii), the mixture was reacted at room temperature over night, and the reaction mixture was concentrated under reduced pressure To the residue was added 200 ml of ether, and it was washed with 2N aqueous solution of sodium hydroxide 2 times and then with water 3 times. The resulting ether layer was dried with anhydrous magnesium sulfate and ether was distilled under reduced pressure. The residue was purified by silica gel chromatography (ethyl acetate/n-hexane=1/4) to give 18.9 g of R-form of 1-(4-(1-ethoxyethyoxy)phenyl)ethanol (yield: 90%).

1. customthe mixture was reacted at room temperature over night
2. concentrationthe reaction mixture was concentrated under reduced pressure To the residue
3. additionwas added 200 ml of ether, and it
4. washwas washed with 2N aqueous solution of sodium hydroxide 2 times
5. dry with materialThe resulting ether layer was dried with anhydrous magnesium sulfate and ether
6. distillationwas distilled under reduced pressure
7. customThe residue was purified by silica gel chromatography (ethyl acetate/n-hexane=1/4)