Phosphorus oxychloride → HCID 23362616, compound

Participants

Reaction Steps

Then, 5 g (0.013 mole) of the obtained ethyl 2-(p-octyloxyphenyl)-4-hydroxypyrimidine-5-carboxylate was dissolved in 25 ml of phosphorus oxychloride, and the mixture was refluxed with heating for 3 hours. The excess phosphorus oxychloride was distilled under reduced pressure, and the residue was purified by silica gel chromatography (developing solvent: CHCl3) to give 4.9 g of ethyl 2-(p-octyloxyphenyl)-4-chloropyrimidine-5-carboxylate (yield: 91%).

Provenance & Evidence