HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(3-Fluorophenyl)piperazine → (RS)-1-ethyl-7-fluoro-8-[3-(3-fluorophenyl)-1-piperazinyl]-4-oxo-1,4-dihydrobenzo[b][1,8]-naphthyridine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(3-Fluorophenyl)piperazine | HCID 3457896 | — |
| Reactant | HCID 19423693 | HCID 19423693 | — |
| Product | (RS)-1-ethyl-7-fluoro-8-[3-(3-fluorophenyl)-1-piperazinyl]-4-oxo-1,4-dihydrobenzo[b][1,8]-naphthyridine-3-carboxylic acid | HCID 54466270 | 87.3% |
Reaction Steps
Working under the conditions of Example 16, but starting with 1-ethyl-7,8-difluoro-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylic acid (1.5 g) and (RS)-2-(3-fluorophenyl)piperazine (1.98 g), (RS)-1-ethyl-7-fluoro-8-[3-(3-fluorophenyl)-1-piperazinyl]-4-oxo-1,4-dihydrobenzo[b][1,8]-naphthyridine-3-carboxylic acid (2 g) is obtained in the form of a yellow solid, m.p. 284° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05053509 |
| Source dataset | uspto-grants-1991_10 |
| ORD ID | ord-a1816d033f0f4828bfbca8f12ab25589 |
| Source note | uspto-grants-1991_10 |