反应详情

温度

10 °C

A solution of potassium permanganate (69.65 g) in water (730 cc) is added in the course of 1 hour to a stirred suspension, cooled to approximately 10° C., of 2-chloro-6,7,8-trifluoro-3-formyl-1,4-dihydroquinoline (45.7 g) in N potassium hydroxide (585 cc), while the temperature is maintained at between 10° and 14° C. The mixture is left stirring for a further 30 minutes at approximately 10° C. Sodium dithionite (12 g) is added and the mixture is stirred for 10 minutes at a temperature in the region of 10° C., filtered through diatomaceous silica and washed with water (3×400 cc). The filtrate and washings are combined and treated with 35% strength aqueous hydrochloric acid solution (70 cc). The precipitate formed is extracted with ethyl acetate (3×500 cc). The combined organic extracts are dried over magnesium sulphate, filtered and concentrated under reduced pressure (20 kPa) at 50° C. The residue is taken up with a mixture of ethyl ether (100 cc) and isopropyl ether (100 cc), drained and washed with the same mixture (100 cc). 2-Chloro-6,7,8-trifluoro-3-quinolinecarboxylic acid (46.43 g) is obtained in the form of a colorless solid, decomposing at 225°-230° C., which is used without further purification for the subsequent steps.

1. temperatureis maintained at between 10° and 14° C
2. waitThe mixture is left
3. stirringthe mixture is stirred for 10 minutes at a temperature in the region of 10° C.
4. filtrationfiltered through diatomaceous silica
5. washwashed with water (3×400 cc)
6. additiontreated with 35% strength aqueous hydrochloric acid solution (70 cc)
7. customThe precipitate formed
8. extractionis extracted with ethyl acetate (3×500 cc)
9. dry with materialThe combined organic extracts are dried over magnesium sulphate
10. filtrationfiltered
11. concentrationconcentrated under reduced pressure (20 kPa) at 50° C
12. additionThe residue is taken up with a mixture of ethyl ether (100 cc) and isopropyl ether (100 cc)
13. washwashed with the same mixture (100 cc)