HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 1514413, compound → HCID 53821322, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 1514413 | HCID 1514413 | — |
| Reactant | 3-Ethoxycarbonyl-7,8,9-trifluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine | HCID 19423688 | — |
| Product | HCID 53821322 | HCID 53821322 | 59.2% |
Reaction Steps
Working under the conditions of Example 39, but starting with 3-ethoxycarbonyl-7,8,9-trifluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine (1.21 g) and (R)-2-phenylpiperazine (0.7 g), and after recrystallization in ethanol (22 cc) containing dimethylformamide (30%), (R)-3-ethoxycarbonyl-7,9-difluoro-1-methyl-4-oxo-8-(3-phenyl-1-piperazinyl)-1,4-dihydrobenzo[b][1,8]naphthyridine (1.02 g) is obtained in the form of a yellow solid, m.p. 216° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05053509 |
| Source dataset | uspto-grants-1991_10 |
| ORD ID | ord-6c915613261b4a6481588ea9c897107d |
| Source note | uspto-grants-1991_10 |