反应详情

Working under the conditions of Example 26, but starting with 3-ethoxycarbonyl-7,8,9-trifluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine (1.38 g) and (S)-2-phenylpiperazine (0.8 g), (S)-3-ethoxycarbonyl-7,9-difluoro-1-methyl-4-oxo -8-(3-phenyl-1-piperazinyl)-1,4-dihydrobenzo[b][1,8]naphthyridine (1.02 g) is obtained in the form of a yellow solid, m.p. 216° C.