3-Ethoxycarbonyl-7,8-difluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine → HCID 54453647, Verbindung

Beteiligte Stoffe

Reaktionsschritte

(RS)-3-Ethoxycarbonyl-7-fluoro-8-[3-(2-fluorophenyl)-1-piperazinyl]-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine was prepared under the conditions of Example 39, but starting with 3-ethoxycarbonyl-7,8-difluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine (1.59 g) and (RS)-2-(2-fluorophenyl)piperazine (1.08 g). After recrystallization in dimethylformamide (60 cc) containing ethanol (50%), the expected product (1.3 g) is obtained in the form of a yellow solid, m.p. 228° C.

Herkunft & Nachweise