反应详情

(RS)-3-Ethoxycarbonyl-1-ethyl-7-fluoro-8-[3-(4-methoxyphenyl)-1-piperazinyl]-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine was prepared under the conditions of Example 33, but starting with 3-ethoxycarbonyl-1-ethyl-7,8-difluoro-4-oxo-1,4-dihydrobenzo [b][1,8]naphthyridine (1.99 g) and (RS)-2-(4-methoxyphenyl)piperazine (2.3 g). (RS)-3-Ethoxycarbonyl-1-ethyl-7-fluoro-8-[3-(4-methoxyphenyl)-1-piperazinyl]-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine (2.2 g) is obtained in the form of a beige solid, m.p. 210°-212° c.

1. custom(RS)-3-Ethoxycarbonyl-1-ethyl-7-fluoro-8-[3-(4-methoxyphenyl)-1-piperazinyl]-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine was prepared under the conditions of Example 33