反应详情

温度

90 °C

A suspension of 1-cyclopropyl-3-ethoxycarbonyl-7,8-difluoro-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine (2 g) and (RS)-3-(4-methoxyphenyl)piperazine (2.3 g) in dimethyl sulphoxide (20 cc) is heated to a temperature in the region of 90° C. for 1 hour and a half. After cooling to approximately 20° C., the insoluble matter is drained, washed with water (3×15 cc) and recrystallized in a mixture of ethanol (100 cc) and dimethylformamide (25 cc). (RS)-1-Cyclopropyl-3-ethoxycarbonyl-7-fluoro-8-[3-(4-methoxyphenyl)-1-piperazinyl]-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine (2.1 g) is obtained in the form of a yellow solid, m.p. 199° C.

1. temperatureAfter cooling to approximately 20° C.
2. washwashed with water (3×15 cc)
3. customrecrystallized in a mixture of ethanol (100 cc) and dimethylformamide (25 cc)