2-(4-nitrophenyl)piperazine → HCID 53739390, compound

Participants

Reaction Steps

(RS)-3-Ethoxycarbonyl-7-fluoro-1-methyl-8-[3-(4-nitrophenyl)-1-piperazinyl]-4-oxo-1,4 -dihydrobenzo[b][1,8]naphthyridine was prepared under the conditions of Example 39, but starting with 3-ethoxycarbonyl-7,8-difluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine (0.636 g) and (RS)-2-(4-nitrophenyl)piperazine (0.5 g). After recrystallization in dimethylformamide (10 cc), the expected product (0.7 g) is obtained in the form of a yellow solid, decomposing at approximately 300° C.

Provenance & Evidence