反应详情

(RS)-1-Cyclopropyl-3-ethoxycarbonyl-7-fluoro-8-[3-(2-furyl)-1-piperazinyl]-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine was prepared under the conditions of Example 39, but starting with 1-cyclopropyl-7,8-difluoro-3-ethoxycarbonyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine (1.05 g) and (RS)-2-(2-furyl)piperazine (0.6 g). (RS)-1-Cyclopropyl-3-ethoxycarbonyl-7-fluoro-8-[3-(2-furyl)-1-piperazinyl]-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine (1.3 g) is obtained in the form of a yellow solid, m.p. 182° C.

1. custom(RS)-1-Cyclopropyl-3-ethoxycarbonyl-7-fluoro-8-[3-(2-furyl)-1-piperazinyl]-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine was prepared under the conditions of Example 39