2-Thiophen-2-yl-piperazine → (RS)-3-Ethoxycarbonyl-7-fluoro-1-methyl-4-oxo-8-[3-(2-thienyl)-1-piperazinyl]-1,4-dihydrobenzo[b][1,8]naphthyridine

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Reaction Steps

(RS)-3-Ethoxycarbonyl-7-fluoro-1-methyl-4-oxo-8-[3-(2-thienyl)-1-piperazinyl]-1,4-dihydrobenzo[b][1,8]naphthyridine was prepared under the conditions of Example 39, but starting with 3-ethoxycarbonyl-7,8-difluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine (1.59 g) and (RS)-2-(2-thienyl)piperazine (1.02 g). (RS)-3-Ethoxycarbonyl-7-fluoro-1-methyl-4-oxo-8-[3-(2-thienyl)-1-piperazinyl ]-1,4-dihydrobenzo[b][1,8]naphthyridine (2.25 g) is obtained in the form of a yellow solid, m.p. 228° C.

Provenance & Evidence