Sodium Carbonate → 3-Ethoxycarbonyl-7-fluoro-8-(4-hydroxy-1-piperazinyl)-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine

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Reaction Steps

3-Ethoxycarbonyl-7-fluoro-8-(4-hydroxy-1-piperazinyl)-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine was prepared under the conditions of Example 39, but starting with 3-ethoxycarbonyl-7,8-difluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8 ]naphthyridine (3 g), 1-hydroxypiperazine dihydrochloride (1.97 g) and sodium carbonate (1.99 g). 3-Ethoxycarbonyl-7-fluoro-8-(4-hydroxy-1-piperazinyl)-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine (3.25 g) is obtained in the form of a yellow solid, m.p. 258°-260° C.

Provenance & Evidence