Potassium Carbonate → 3-Ethoxycarbonyl-7,9-difluoro-8-(4-hydroxy-1-piperazinyl)-1-methyl-4-oxo-1,4-dihydrobenzo [b][1,8]naphthyridine

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Reaction Steps

3-Ethoxycarbonyl-7,9-difluoro-8-(4-hydroxy-1-piperazinyl)-1-methyl-4-oxo-1,4-dihydrobenzo [b][1,8]naphthyridine was prepared under the conditions of Example 39, but starting with 3-ethoxycarbonyl-7,8,9-trifluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine (1.9 g), 1-hydroxypiperazine dihydrochloride (1 g) and potassium carbonate (1.6 g). 3-Ethoxycarbonyl-7,9-difluoro-8-(4-hydroxy-1-piperazinyl)-1-methyl-4-oxo-1,4-dihydrobenzo [b][1,8]naphthyridine (1.4 g) is obtained in the form of a yellow solid, m.p. 255°-258° C.

Provenance & Evidence