HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 344967Generated: October 25, 2026
Potassium Hydroxide → 7-nitro-3,4-dihydro-2H-1,4-benzoxazin-3-one
https://huagongshe.com/reaction/344967
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 2-chloro-N-(2-hydroxy-4-nitrophenyl)acetamide | HCID 19968389 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 7-nitro-3,4-dihydro-2H-1,4-benzoxazin-3-one | HCID 2763830 | 85% |
Reaction Steps
A mixture of 8 (22 g) and powdered KOH (6.9 g) in DMSO (100 ml) was stirred at 95° C. for 30 min. and poured onto crushed ice (400 g). The resulting precipitate was collected and washed with H2O to give 9 (15.7 g, 85%): mp 230°-232° C.; MS m/e 194 (M+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05055110 |
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| Source dataset | uspto-grants-1991_10 |
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| ORD ID | ord-9da82c2c5dd74825809ab764a9740475 |
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| Source note | uspto-grants-1991_10 |
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