Phenothiazine → HCID 19992664, compound

Participants

Reaction Conditions

Reaction Steps

2.5 ml of a 40% strength methanolic solution of benzyltrimethylammonium hydroxide are added dropwise to a reactor containing 100 g (0.5 moles) of phenothiazine and 530 g (10 moles) of acrylonitrile and cooled to a temperature below 10° C. The whole is heated to 80° C. for 1 hour 30 min. The excess acrylonitrile is removed by vacuum distillation. The solid is recrystallized twice from acetone. 10-Phenothiazinylproprionitrile is obtained in a 66% yield (83.9 g). M.p.: 156°-157° C.

Provenance & Evidence