反应详情

Methanesulphonyl chloride (6.2 ml) was added dropwise to a stirred solution of 6-amino-2-methylquinoline (12.5 g) in pyridine (100 ml) cooled to 5°. Stirring was continued for 17 hours at room temperature. The pyridine was then removed by evaporation in vacuo, the residue diluted with aqueous sodium bicarbonate, and extracted three times with methylene chloride. The combined organic extracts were combined, dried (MgSO4) and evaporated in vacuo to give the title compound, yield 13.0 g, m.p. 151°-153°.

1. temperaturecooled to 5°
2. customThe pyridine was then removed by evaporation in vacuo
3. additionthe residue diluted with aqueous sodium bicarbonate
4. extractionextracted three times with methylene chloride
5. dry with materialdried (MgSO4)
6. customevaporated in vacuo