HCID 14648650, compound → HCID 67931152, compound

Participants

Reaction Steps

A mixture of 17.98 g of 3-amino-3-methoxycarbonyl-4-phenyl-1,3,4,5-tetrahydro-1-benzazepin-2(2H)-one, 21.76 g of lithium iodide trihydrate and 400 ml of dried pyridine is stirred under reflux for 2 days. To the residue obtained after the mixture is concentrated under reduced pressure, an aqueous solution of potassium carbonate, an aqueous solution of sodium thiosulfate and chloroform are added, and the organic substance is extracted. The chloroform layer is dried and concentrated. The obtained residue is subjected to silica gel chromatography (eluent: chloroform:methanol =20:1) to give 5.6 g of cis-3-amino-4-phenyl-1,3,4,5-tetrahydro-1-benzazepin-2(2H)-one and 5.44 g of trans-3-amino-4-phenyl-1,3,4,5-tetrahydro-benzazepin-2(2H)-one.

Provenance & Evidence