反应详情

In 12.5 ml of dichloromethane, were dissolved 2.5 g (20.7 mmol) of benzaldoxime and 2.1 g (25.0 mmol) of 1-pentyne-3-ol. Under ice cooling, 14.5 g of a 12.0% aqueous solution of sodium hypochlorite were added dropwise addition, they were reacted at room temperature for 3 hours, followed by the extraction of the organic layer with dichloromethane. The extract was washed with water and the resulting organic layer was dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure and the residue was purified by chromatography on a silica gel column (eluent: chloroform), whereby the target compound, namely, 5-(1-hydroxypropyl)-3-phenylisooxazole was obtained as crystals.

1. additionaddition, they
2. customwere reacted at room temperature for 3 hours
3. extractionfollowed by the extraction of the organic layer with dichloromethane
4. washThe extract was washed with water
5. dry with materialthe resulting organic layer was dried over anhydrous sodium sulfate
6. distillationThe solvent was distilled off under reduced pressure
7. customthe residue was purified by chromatography on a silica gel column (eluent: chloroform), whereby the target compound