3,4-dihydro-2H-pyran → HCID 54519216, compound

Participants

Reaction Steps

To dihydropyran (1.3 g) cooled in an ice bath was added (3R*,4R*)-3-methyl-1-pentyn-4-ol (1.3 g) followed by concentrated hydrochloric acid (1 drop) and the mixture was stirred for 16 h at room temperature. Potassium carbonate (100 mg) was added and the mixture stirred for 15 minutes. Diethyl ether (10 ml) was added and the mixture was filtered before evaporation to an oil. The residue was distilled to give the title compound (1.2 g) (b.p. 130°-5° C. at 10 mm Hg).

Provenance & Evidence