反应详情

A solution of 24.4 g (0.24 mol) of 3-hydroxy-2,2-dimethylpropanal (Aldrich), 26 g (0.25 mol) of trimethyl orthoformate, and 0.5 mL of 6.8 N HCl/dioxane in 300 mL of methanol was allowed to stand at room temperature overnight. A slight excess of NaOCH3 was added and the solvent evaporated at reduced pressure. The residue was dissolved in ether and the mixture filtered. After evaporation of solvent and fractionation twice through a 15 cm Vigreux column, the product was obtained as a water white oil, bp 43°-48°/0.2mm, 18.5 g (52%).

1. customthe solvent evaporated at reduced pressure
2. dissolutionThe residue was dissolved in ether
3. filtrationthe mixture filtered
4. customAfter evaporation of solvent and fractionation twice through a 15 cm Vigreux column
5. customthe product was obtained as a water white oil, bp 43°-48°/0.2mm, 18.5 g (52%)