4-Chlorophenyl Isocyanate → Urea, N-(4-chlorophenyl)-N'-((5-oxo-1-(phenylmethyl)-3-pyrrolidinyl)methyl)-

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Reaction Steps

52 g (0.25 mol) of 4-aminomethyl-1-benzylpyrrolidin-2-one are stirred for 2 hours at ambient temperature in 70 ml of dioxane with 38 g (0.25 mol) of p-chlorophenylisocyanate and the solution is then evaporated in vacuo. The residue crystallizes out of ethyl acetate to yield 67 g of the title compound, m.p. 139°-140° C.

Provenance & Evidence