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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 345253Generated: October 30, 2026

Trimethyl orthoformate → 8-Oxo-2-methoxy-3-oxa-1-azabicyclo[4.2.0]octane

https://huagongshe.com/reaction/345253

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrimethyl orthoformateHCID 9005—
ReactantHCID 12769229HCID 12769229—
Product8-Oxo-2-methoxy-3-oxa-1-azabicyclo[4.2.0]octaneHCID 19993997—

Reaction Steps

Following the procedure described for the preparation of 8-oxo-2,2-dimethyl-3-oxa-1-azabicyclo[4.2.0]octane from 4-(2-40 -hydroxyethyl)-2-azetidinone and using trimethyl orthoformate instead of 2,2-dimethoxypropane one obtains 8-oxo-2-methoxy-3-oxa-1-azabicyclo[4.2.0]octane.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05055573
Source datasetuspto-grants-1991_10
ORD IDord-aa0514d74bdf4944b75d77247b35abfd
Source noteuspto-grants-1991_10