Hydrochloric Acid → {[(1,3-Benzothiazol-2-yl)amino]methylene}bis(phosphonic acid)

Participants

Reaction Steps

4.36 g (10 mmol) of 1-(benzothiazol-2-ylamino)methane-1,1-diphosphonic acid tetraethyl ester are heated in 40 ml of N hydrochloric acid at 110°-120° for 6 hours. In the course of the reaction, the product separates out in the form of a white precipitate. After cooling to room temperature, filtration is carried out and the product is washed with aqueous methanol. 3.09 g (95% of the theoretical yield) of 1-(benzothiazol-2-yl-amino)methane-1,1-diphosphonic acid of m.p. 290° (decomposition) are obtained.

Provenance & Evidence