Sodium Hydroxide → HCID 86745156, compound

HRID 345286Notes

Reaction equation

HRID 345286 reaction equation
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[NH:6][CH:7]([P:12]([OH:15])(=[O:14])[OH:13])[P:8]([OH:11])(=[O:10])[OH:9].[OH-].[Na+:17]>O>[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[NH:6][CH:7]([P:8]([OH:11])(=[O:9])[OH:10])[P:12]([O-:14])(=[O:13])[O-:15].[Na+:17].[Na+:17]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 405391{[(1,3-Thiazol-2-yl)amino]methylene}bis(phosphonic acid)

Product 1

HCID 86745156HCID 86745156, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2.74 g of 1-(thiazol-2-ylamino)methane-1,1-diphosphonic acid (example 1 ) are suspended in 10 ml of water. While stirring, 10 ml of 2N aqueous sodium hydroxide solution are added dropwise to the suspension. The resulting solution is evaporated to dryness. 40 ml of methanol are added to the resulting viscous residue and the mixture is stirred thoroughly. The resulting crystalline precipitate is filtered off and dried, yielding the disodium 1-(thiazol-2-ylamino)methane-1,1-diphosphonate of the formula ##STR10## which has a melting point of more than 320°.

Workup

  1. customThe resulting solution is evaporated to dryness
  2. addition40 ml of methanol are added to the resulting viscous residue
  3. stirringthe mixture is stirred thoroughly
  4. filtrationThe resulting crystalline precipitate is filtered off
  5. customdried

Sources & evidence

ORD record
ord-e59c527a5834459c95dce7b87f6ce9e1
Source dataset
uspto-grants-1991_10
Patent number
US05057505

Reaction notes

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