Silver Nitrate → HCID 86745157, compound

HRID 345287Notes

Reaction equation

HRID 345287 reaction equation
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[NH:6][CH:7]([P:12]([OH:15])(=[O:14])[OH:13])[P:8]([OH:11])(=[O:10])[OH:9].[N+]([O-])([O-])=O.[Ag+:20]>O>[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[NH:6][CH:7]([P:8]([OH:11])(=[O:9])[OH:10])[P:12]([O-:14])(=[O:13])[O-:15].[Ag+:20].[Ag+:20]

Participants

4

Reactant 2

HCID 24470Silver NitrateHCID 405391{[(1,3-Thiazol-2-yl)amino]methylene}bis(phosphonic acid)

Product 1

HCID 86745157HCID 86745157, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

0.954 mg of 1-(thiazole-2-ylamino)methane-1,1-diphosphonic acid (example 1) are dissolved in 10 ml of water. A solution of 1.018 g of silver nitrate in 5 ml of water is added dropwise, while stirring. The mixture is then stirred for another 30 minutes. The precipitate is filtered off and washed successively with methanol and diethyl ether, yielding the disilver 1-(thiazol-2-ylamino)-methane-1,1-diphosphonate, which has a melting point of more than 320°.

Workup

  1. stirringThe mixture is then stirred for another 30 minutes
  2. filtrationThe precipitate is filtered off
  3. washwashed successively with methanol and diethyl ether

Sources & evidence

ORD record
ord-ef04fdd562924ea59633af5e6162b9ba
Source dataset
uspto-grants-1991_10
Patent number
US05057505

Reaction notes

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