2-Propyl-2-oxetanemethanol → 4-n-Propyl-1-(2-pyridyl)-2,6,7-trioxabicyclo[2.2.2]octane

HRID 345290Notes

Reaction equation

HRID 345290 reaction equation
C1(C23COC([C:15]4[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=4)(OC2)OC3)CCCCC1.[CH:21]1([C:27]2([CH2:31][OH:32])[CH2:30][O:29][CH2:28]2)[CH2:26][CH2:25]CCC1.C1(C(CO)(CO)[CH2:40][OH:41])CCCCC1.OCC1(CCC)COC1>>[CH2:21]([C:27]12[CH2:30][O:29][C:28]([C:17]3[CH:16]=[CH:15][CH:20]=[CH:19][N:18]=3)([O:32][CH2:31]1)[O:41][CH2:40]2)[CH2:26][CH3:25]

Participants

5

Reactant 4

HCID 1838902-Propyl-2-oxetanemethanolHCID 129305402-Cyclohexyl-2-hydroxymethylpropan-1,3-diolHCID 19373305(3-Cyclohexyloxetan-3-yl)methanolHCID 199920154-Cyclohexyl-1-(4-pyridyl)-2,6,7-trioxabicyclo[2.2.2]octane

Product 1

HCID 199920184-n-Propyl-1-(2-pyridyl)-2,6,7-trioxabicyclo[2.2.2]octane

Procedure

4-Cyclohexyl-1-(4-pyridyl)-2,6,7-trioxabicyclo[2.2.2]octane (from 3-cyclohexyl-3-hydroxymethyloxetane which was prepared from 2-cyclohexyl-2-hydroxymethylpropan-1,3-diol in a manner described for the synthesis of 3-hydroxymethyl-3-n-propyloxetane).

Sources & evidence

ORD record
ord-6196758402a04a2da8dee1276aeb6106
Source dataset
uspto-grants-1991_10
Patent number
US05057504

Reaction notes

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