HCID 19992023, compound → HCID 19991999, compound

Participants

Reaction Steps

To a solution of benzyl 3-(4-n-propyl-2,6,7-trioxabicyclo[2.2.2]oct-1-yl)piperidine-1-carboxylate (7.0 g.) in dry tetrahydrofuran (100 ml) under nitrogen, was added 5% palladium on carbon (0.63 g.) and the system was hydrogenated at atmospheric pressure. When the theoretical volume uptake (450 ml) had been achieved the system was purged with nitrogen and the mixture was filtered through celite. The solution was evaporated in vacuo. The resulting solid was recrystallised from hexane. 3-(4-n-Propyl-2,6,7-trioxabicyclo[2.2.2]oct-1-yl)piperidine (3.3 g.) was obtained as colourless crystals.

Provenance & Evidence