2-Aminothiophenol → HCID 86745158, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-phenylmethyl-1-carboxymethylenecyclohexane (3.0 g) and 2-aminothiophenol (5.0 g) in N,N-dimethylformamide (3 ml) was refluxed for 20 hours under nitrogen atmosphere. The mixture was cooled to 0° C. and diluted with ethyl acetate (30 ml) and the mixture was washed with 1N hydrochloric acid (30 ml), water (30 ml), a saturated aqueous solution of sodium bicarbonate (30 ml) and brine (30 ml). The organic layer was dried over magnesium sulfate and concentrated in vacuo. The residue was triturated with diethyl ether to give 2'-phenylmethyl-4,5-dihydro-4-oxospiro[1,5-benzothiazepine-2(3H), 1'-cyclohexane] (2.2 g).

Provenance & Evidence