Sodium Sulfite → HCID 19992148, compound

Participants

Reaction Steps

To a solution of 1-phenylmethyl-11-oxo-7-thia-10-azaspiro[5.6]dodecane (2.5 g) in methylene chloride (80 ml) was added 80% m-chloroperbenzoic acid (3.8 g) at 0° C. After one hour, a saturated aqueous solution (50 ml) of sodium sulfite was added to the solution. The organic layer was washed with brine (50 ml), dried over magnesium sulfate and concentrated in vacuo. The residue was triturated with diethyl ether to give 1-phenylmethyl-11-oxo-7-thia-10-azaspiro[5.6]dodecane 7,7-dioxide (2.37 g).

Provenance & Evidence