Pyridine → HCID 67928912, compound

HRID 345305Notes

Reaction equation

[C:1]1([CH2:7][CH:8]2[C:13]3([CH2:19][C:18](=[O:20])[N:17]([CH2:21][CH2:22][CH2:23][CH2:24][Br:25])[CH2:16][CH2:15][S:14]3(=[O:27])=[O:26])[CH2:12][CH2:11][CH2:10][CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[N:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[Br-:25].[C:1]1([CH2:7][CH:8]2[C:13]3([CH2:19][C:18](=[O:20])[N:17]([CH2:21][CH2:22][CH2:23][CH2:24][N+:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)[CH2:16][CH2:15][S:14]3(=[O:27])=[O:26])[CH2:12][CH2:11][CH2:10][CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

Reactant 2

HCID 1049Pyridine

HCID 19992163HCID 19992163, compound

Product 1

HCID 67928912HCID 67928912, compound

Procedure

1-Phenylmethyl-10-(4-bromobutyl)-11-oxo-7-thia-10-azaspiro[5.6]dodecane 7,7-dioxide (0.34 g) in pyridine (5 ml) was refluxed for thirty minutes. Then pyridine was evaporated in vacuo to give 1-phenylmethyl-10-{4-(1-pyridinio)butyl}-11-oxo-7-thia-10-azaspiro[5.6]dodecane 7,7-dioxide bromide (0.42 g).

Workup

customThen pyridine was evaporated in vacuo

Sources & evidence

ORD record: ord-3c72b740a2e64fa383325317eacb49d6
Source dataset: uspto-grants-1991_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05057513

Reaction notes

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