Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 345314Generated: October 26, 2026

m-Chloroperbenzoic acid → 3-(Diethylphosphonomethyl)-2-cyanopyridine

https://huagongshe.com/reaction/345314

Reaction equation

Participants

RoleNameHCIDCharge
Reactantm-Chloroperbenzoic acidHCID 70297—
ReactantTrimethylsilyl cyanideHCID 82115—
Reactant3-(Diethoxyphosphorylmethyl)pyridineHCID 10462605—
Product3-(Diethylphosphonomethyl)-2-cyanopyridineHCID 54233382—
Product5-(Diethylphosphonomethyl)-2-cyanopyridineHCID 54489936—

Reaction Steps

Treatment of 3-(diethylphosphonomethyl)pyridine (Biochemistry 19, 3400) with m-chloroperbenzoic acid followed by trimethylsilyl cyanide gives both 3-(diethylphosphonomethyl)-2-cyanopyridine and 5-(diethylphosphonomethyl)-2-cyanopyridine, the starting materials for compounds under a) and b).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05057506
Source datasetuspto-grants-1991_10
ORD IDord-ac012df2c4b64d1180f2043e91bddbdb
Source noteuspto-grants-1991_10