HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Pyridineethanol → 4-(2-Hydroxyethyl)pyridine-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Pyridineethanol | HCID 72921 | — |
| Reactant | Trimethylsilyl cyanide | HCID 82115 | — |
| Reactant | 4-(2-hydroxyethyl)-pyridine-N-oxide | HCID 19757841 | — |
| Product | 4-(2-Hydroxyethyl)pyridine-2-carbonitrile | HCID 22321661 | — |
Reaction Steps
4-(2-hydroxyethyl)-pyridine is oxidized to 4-(2-hydroxyethyl)-pyridine-N-oxide which is in turn treated with trimethylsilyl cyanide to yield 4-(2-hydroxyethyl)-2-cyanopyridine which is converted to ethyl 4-(2-hydroxyethyl)-2-pyridine carboxylate and then hydrogenated to yield ethyl 4-(2-hydroxyethyl)-piperidine-2-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05057506 |
| Source dataset | uspto-grants-1991_10 |
| ORD ID | ord-29dec4aa133440e580d6148243ca40e1 |
| Source note | uspto-grants-1991_10 |