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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 345350Generated: October 31, 2026

Ethyl 4-(hydroxymethyl)picolinate → Ethyl 4-(hydroxymethyl)-piperidine-2-carboxylate

https://huagongshe.com/reaction/345350

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 4-(hydroxymethyl)picolinateHCID 14541449—
CatalystPlatinum oxide (PtO)HCID 82844—
SolventAcetic AcidHCID 176—
ProductEthyl 4-(hydroxymethyl)-piperidine-2-carboxylateHCID 19757810—

Reaction Steps

A mixture of 13.9 g of ethyl 4-(hydroxymethyl)-pyridine-2-carboxylate, 5 g platinum oxide in 250 ml acetic acid is hydrogenated at 50 lbs/in2Filtration, concentration in vacuo, and neutralization with potassium carbonate in methylene chloride yields an oil that is purified by flash chromatography using methylene chloride/methanol saturated with ammonia (20:1) to yield ethyl 4-(hydroxymethyl)-piperidine-2-carboxylate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05057506
Source datasetuspto-grants-1991_10
ORD IDord-e813e6eddbe546fd8caa68454d949046
Source noteuspto-grants-1991_10