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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 345368Generated: October 25, 2026

Diethyl isobutylmalonate → 2-Isobutyl-2-hydroxymethylpropan-1,3-diol

https://huagongshe.com/reaction/345368

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiethyl isobutylmalonateHCID 25047—
ReactantDiethyl 2-cyclohexylmalonateHCID 240541—
ReactantHCID 18953343HCID 18953343—
Product2-Isobutyl-2-hydroxymethylpropan-1,3-diolHCID 12930535—
Product2-Cyclohexyl-2-hydroxymethylpropan-1,3-diolHCID 12930540—

Reaction Steps

2-Cyclohexyl-2-hydroxymethylpropan-1,3-diol and 2-isobutyl-2-hydroxymethylpropan-1,3-diol were prepared from diethyl cyclohexylmalonate and diethyl i-butylmalonate respectively in a manner analogous to the synthesis of 2-(2,2-dimethylpropyl)-2-hydroxymethylpropane-1,3-diol (example 5).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05057508
Source datasetuspto-grants-1991_10
ORD IDord-7143617fdcb649e39bc99f110f3dd518
Source noteuspto-grants-1991_10