Formic Acid → HCID 178517229, compound

HRID 345396Notes

Reaction equation

HRID 345396 reaction equation
[NH2:1][C:2]1[C:11]([NH2:12])=[C:10]([Cl:13])[CH:9]=[C:8]2[C:3]=1[N:4]=[C:5]([OH:15])[C:6]([OH:14])=[N:7]2.[CH:16](O)=O>O>[Cl:13][C:10]1[CH:9]=[C:8]2[C:3]([N:4]=[C:5]([OH:15])[C:6]([OH:14])=[N:7]2)=[C:2]2[NH:1][CH:16]=[N:12][C:11]=12

Participants

4

Reactant 2

HCID 284Formic AcidHCID 178507817HCID 178507817, compound

Product 1

HCID 178517229HCID 178517229, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
25 °C

Procedure

A mixture of 0,3 g (1,35 mmol) 5,6-diamino-7-chloro-2,3-dihydroxyquinoxaline and 8 ml formic acid was refluxed for 2 h. After cooling to 25° C., the reaction mixture was poured into 30 ml water to give 0,21 g (67%) 4-chloro-7,8-dihydroxy-1H-imidazo(4,5-f)quinoxaline, m.p.>300° C. NMR (DMSO-d6) 7.37 (1H,s), 6.70 (1H,s).

Workup

  1. temperaturewas refluxed for 2 h

Sources & evidence

ORD record
ord-346c7badb3ff4075a79d985111407c92
Source dataset
uspto-grants-1991_10
Patent number
US05057516

Reaction notes

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