Nitric Acid → HCID 14578864, compound

Participants

Reaction Steps

4.5 g. 1,3-Dihydro-3,3-dimethyl-6-hydroxy-2H-indol-2-one were added portionwise, with vigorous stirring, to 35 ml. 65% nitric acid which was cooled with a mixture of ice and salt. The reaction mixture was further stirred in the cold for 10 minutes, diluted with ice/water to 150 ml. and the crystalline precipitate filtered off with suction and subsequently washed with water to give 4.1 g. (73% of theory) of the title compound in the form of yellow crystals; m.p. 244°-247° C.

Provenance & Evidence