Ammonia → HCID 19992378, compound

Participants

Reaction Steps

4.52 g. 5-Amino-1,3-dihydro-3,3-dimethyl-6-hydroxy-2H-indol-2-one hydrochloride and 3.65 g. 4-pyridylacetic acid were heated in 20 g. polyphosphoric acid for 30 minutes to 170° C. and the reaction mixture subsequently poured on to ice. A concentrated aqueous solution of ammonia was added thereto to give a pH of 10, the precipitate obtained was filtered off with suction, successively washed with water, methanol and diethyl ether and then dried to constant weight to give 3.20 g. (55% of theory) of the title compound; m.p. 208°-211° C.

Provenance & Evidence